SCREENING OF CERTAIN ANAESTHETIC AGENTS FOR THEIR ABILITY TO ELICIT ACUTE PORPHYRIC PHASES IN SUSCEPTIBLE PATIENTS
Open Access
- 1 August 1980
- journal article
- research article
- Published by Elsevier in British Journal of Anaesthesia
- Vol. 52 (8) , 759-762
- https://doi.org/10.1093/bja/52.8.759
Abstract
The activity of δ-aminolaevulinic acid synthetase (E.C. 2.3.1.37) (ALA-S) was measured in rat liver after the simultaneous administration of various anaesthetic agents and 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) in vivo. Flunitrazepam, Althesin and phenobarbitone caused a significant increase in the activity of the enzyme which was not observed with propanidid, etomidate and minaxolone. It is suggested that DDC-treated rat, which resembles latent human variegate porphyria may be a more valid method of testing drugs for their ability to elicit acute porphyric phases in susceptible individuals. The anaesthetic agents which induced the activity of hepatic ALA-S in this model are not recommended in patients with genetic hepatic porphyria.This publication has 5 references indexed in Scilit:
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