Constituents of Withania somnifera Dun. Part VI. The stereochemistry of withaferin A
- 1 January 1966
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society C: Organic
- p. 1753-1756
- https://doi.org/10.1039/j39660001753
Abstract
Withaferin A, the steroidal lactone isolated from the leaves of Withania somnifera Dun. (Solanaceae), has been degraded to bisnor-(5α)-cholanic acid. The β-orientation of the 5,6-epoxide has been demonstrated by optical rotatory dispersion and n.m.r. data. Consequently, withaferin A is a 5β-steroid with the usual stereochemistry at all asymmetric centres, possessing a six-membered-ring lactone in the side-chain.Keywords
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