Combinatorial Synthesis of C(2), C(3)-Disubstituted 3-Hydroxypropionamides Utilizing Baylis-Hillman Reactions on Solid Support
- 1 March 1997
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1997 (3) , 325-326
- https://doi.org/10.1055/s-1997-769
Abstract
A four-step reaction protocol for multiple polymer-supported synthesis of structurally diverse α,β-disubstituted 3-hydroxypropionamides 10 has been developed. Variable building blocks were recruited from three monomer pools: primary/secondary amines and aryl aldehydes, the latter of which underwent incorporation into target molecules via Baylis-Hillman reactions. The potential of our approach is demonstrated by machine-assisted assemblage of a small prototype library.Keywords
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