Abstract
Surprisingly, the Canadian multicenter study of the efficacy of a combination of lecithin and tetrahydroaminoacridine (THA) in the treatment of Alzheimer's disease (May 5 issue)1 failed to include an untreated control group; all patients received lecithin throughout the study, and the efficacy of THA was tested by comparing the responses to lecithin plus THA with those to lecithin alone. Hence, if the high doses of purified lecithin taken by the subjects had any positive effect on their subsequent performance, this effect might have obscured that of adding THA.