VAGINAL SEPTA IN MICE - INCIDENCE, INHERITANCE, AND EFFECT ON REPRODUCTIVE-PERFORMANCE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 26  (6) , 895-898
Abstract
Dorso-ventral septa were observed in 38% of the recently weaned BALB/cJ female mice in the production colony at The Jackson Laboratory [Bar Harbor, Maine, USA]. The frequency of septa in 2 other BALB/c substrains and 8 different inbred strains ranged from 0-8%. The vaginal anomaly was similar regardless of genetic background although individual variations were observed. The remainder of the reproductive tract was normal. Microscopically, the septum consisted of a fibrous partition covered by normal epithelium. Genetic analysis was undertaken by outcrossing septate BALB/cJ females to C57BL/6J, DBA/2J or BALB/cBy males. Examination of female F1 and F2 progeny indicated more than 1 recessive gene was involved and genetic background influenced expression of these genes. Reproductive performance of septate and nonseptate BALB/cJ females was compared using several criteria. Fewer septate females were fertile but the fecundity of fertile septate females was not affected.

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