Give Me Air! — But Not Much

Abstract
In 1891, Dr. Wizard of Chamonix made a careful report of an autopsy he had performed on his professional colleague, Dr. Jacottet, "a robust young man," who had died at an altitude of 4350 m after ascending Mont Blanc (4807 m). The lungs showed considerable edema; the heart was normal. In retrospect we can surmise that this was the first recorded case of high-altitude pulmonary edema (HAPE). Despite obscure clinical reports from Peru from 1913 onwards1 , 2 detailed physiologic investigation of HAPE did not begin until the problem got closer to home with Houston's report from Aspen, Colorado.3 Parochially, it has . . .

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