Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cells
Top Cited Papers
Open Access
- 15 June 2006
- journal article
- research article
- Published by American Society of Hematology in Blood
- Vol. 107 (12) , 4907-4916
- https://doi.org/10.1182/blood-2005-08-3531
Abstract
Multiple myeloma (MM) is an incurable plasma cell malignancy. The 26S proteasome inhibitor, bortezomib, selectively induces apoptosis in MM cells; hoKeywords
This publication has 107 references indexed in Scilit:
- Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress responseThe Journal of cell biology, 2004
- An Integrated Stress Response Regulates Amino Acid Metabolism and Resistance to Oxidative StressPublished by Elsevier ,2003
- Heat Shock Protein 90 Modulates the Unfolded Protein Response by Stabilizing IRE1αMolecular and Cellular Biology, 2002
- Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell SurvivalPublished by Elsevier ,2001
- Posttranslational Quality Control: Folding, Refolding, and Degrading ProteinsScience, 1999
- Setting the Standards: Quality Control in the Secretory PathwayScience, 1999
- Proteasome Inhibitors MG132 and Lactacystin Hyperphosphorylate HSF1 and Induce hsp70 and hsp27 ExpressionBiochemical and Biophysical Research Communications, 1999
- Proteasome-Dependent Regulation of p21WAF1/CIP1ExpressionBiochemical and Biophysical Research Communications, 1996
- Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas.The Journal of cell biology, 1986
- Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinaseBiochemical and Biophysical Research Communications, 1986