Lipase-Catalyzed Enantiotoposelective Hydrolysis ofmeso-Compounds Derived from 2- Cyclohexene-1,4-Diol: Synthesis of (-)-Conduritol C, (-)-Conduritol E, (-)-Conduritol F and a Homochiral Derivative of Conduritol A
- 1 January 1992
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1992 (03) , 243-245
- https://doi.org/10.1055/s-1992-21329
Abstract
The lipase-catalyzed enantiotoposelective hydrolysis of diacetate 2 leads to the 4-acetoxy-2-cyclohexen-1-ols (+)-3 or (-)-3 with good enantiomeric excess, while the dibutyrates 5 and 10 afforded alcohols (+)-6 and (+)-11 in >95% ee. The synthesis of (-)-conduritol C, (-)-conduritol E and (-)-conduritol F and a homochiral derivative of conduritol A from (+)-6 and (+)-11 is described.Keywords
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