LY 1+2- SUPPRESSOR T-CELLS DOWN-REGULATE THE GENERATION OF LY 1-2+ EFFECTOR T-CELLS DURING PROGRESSIVE GROWTH OF THE P815 MASTOCYTOMA

  • 1 January 1985
    • journal article
    • research article
    • Vol. 54  (1) , 47-56
Abstract
It has been shown that progressive growth of the P815 mastocytoma in its semisyngeneic B6D2 host results, between days 6 and 9 of tumor growth, in the generation of Ly 1- 2+ T cells which are capable, on passive transfer, of causing the regression of an established tumor in .gamma.-irradiated recipients, and of T cells which are capable of lysing P815 tumor cells in vitro. After 9 days of tumor growth, these effector T cells are progressively lost; this is associated with the progressive acquisition of Ly 1+2- suppressor T cells which are capable of inhibiting the expression of passively transferred immunity against an established tumor in T-cell deficient recipients. Evidently, this P815 mastocytoma grows progressively, in spite of its immunogenicity, because it evokes the generation of suppressor T cells before enough effector T cells are generated to reject it.

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