YELLOW MUTANT ALBINISM - CYTOCHEMICAL, ULTRASTRUCTURAL, AND GENETIC-CHARACTERIZATION SUGGESTING MULTIPLE ALLELISM

  • 1 January 1980
    • journal article
    • research article
    • Vol. 32  (3) , 387-395
Abstract
Three sisters, including monozygotic (MZ) twins, with clinical, ultrastructural and histochemical features typical of yellow mutant albinism are described. This form of albinism is clinically similar to the tyrosinase-positive type, but hair bulbs showed organelles similar to red hair pheomelanosomes and absence of tyrosinase activity. Classical tyrosinase-negative albinism was found in a maternal cousin of the probands. Pedigree analysis of this family suggests multiple alleles occupying a single locus.