THE TRYPANOCIDAL ACTIVITY OF SOME PYRIMIDYL‐AMINOPHENYLARSONIC COMPOUNDS
Open Access
- 1 September 1958
- journal article
- research article
- Published by Wiley in British Journal of Pharmacology and Chemotherapy
- Vol. 13 (3) , 244-249
- https://doi.org/10.1111/j.1476-5381.1958.tb00898.x
Abstract
A series of substituted pyrimidylaminophenylarsonic acids have been prepared, reduced to the corresponding oxophenylarsines and finally, in certain cases, to the arsenobenzenes. The tervalent arsenicals were highly active against Trypanosoma rhodesiense in mice. 4-(2:6-Diaminopyrimid-4-ylamino)phenyloxoarsine either as the insoluble carbonate or the soluble isethionate was the most promising of these compounds.Keywords
This publication has 2 references indexed in Scilit:
- Arylaminoheterocycles. IV. Arsenicals of AnilinopyrimidinesJournal of the American Chemical Society, 1946
- Trypanocidal and Spirochetocidal Arsenicals Derived from s-TriazineJournal of the American Chemical Society, 1944