COMPLEMENT IN INDUCTION OF IGE ANTIBODY-FORMATION

  • 1 January 1977
    • journal article
    • research article
    • Vol. 27  (3) , 397-400
Abstract
The Ig[immunoglobulin]E antibody response of NIH mice to ovalbumin was suppressed by in vivo complement depletion was cobra [venom] factor. This observation extends to IgE the finding that complement participates in thymus-dependent antibody formation. Control mice producing IgE anti-ovalbumin antibody after boosting all developed marked peripheral eosinophilia; mice in which the IgE antibody response was suppressed by cobra factor did not. Administration of cobra factor itself had no effect on peripheral eosinophil levels.