Effect of Hypoxic Guinea Pig Plasma Upon Erythropoiesis in the Polycythemic Mouse and Polycythemic Guinea Pig
- 1 January 1964
- journal article
- research article
- Published by S. Karger AG in Acta Haematologica
- Vol. 31 (6) , 329-337
- https://doi.org/10.1159/000209647
Abstract
Plasma obtained from guinea pigs made hypoxic for 24 hours induced the greatest response of Fe59 incorporation into the red cells in both assay animals. The sensitivity of the assay for ery-thropoietin was compared in the hypoxic-induced polycythemic mouse and in the hypertransfused polycythemic mouse. The hypoxic-induced polycythemic mouse assay proved more sensitive, detecting smaller titers of erythropoietin activity in the plasmas from guinea pigs subjected to hypoxia for 48 and 72 hours. Most but not all of the erythro-poietic activity was lost in phenol extracts of plasma from guinea pigs rendered hypoxic for 24 hours.Keywords
This publication has 1 reference indexed in Scilit:
- Presence of Plasma Erythropoietin in Hypoxic Rats with or without Kidney(s) and/or SpleenExperimental Biology and Medicine, 1957