Synthesis of (R)-4-Oxo-5-phosphononorvaline, anN-Methyl-D-aspartic Acid Receptor Selective β-Keto Phosphonate
- 1 January 1994
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1994 (08) , 851-854
- https://doi.org/10.1055/s-1994-25588
Abstract
(R)-4-Oxo-5-phosphononorvaline (1), a selective NMDA glutamate site antagonist, has been synthesized in four steps (overall yield = 31%) from (R)-aspartic acid, without racemization.Keywords
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