RELATION OF FIBRILLATION TO ACETYLCHOLINE AND POTASSIUM SENSITIVITY IN DENERVATED SKELETAL MUSCLE

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Abstract
Denervation renders skeletal muscle much more sensitive to acetylcholine and, less markedly, to KCl. Small concs. of these agents, when injected intra-arterially, produced action potentials comparable to and superimposed on those of fibrillation. This excitation was abolished by quinidine in doses which arrest fibrillation. The fibrillation seen in skeletal muscle after lower motor neurone denervation may arise from an increased sensitivity of denervated muscle to chemically-induced excitation. The present expts. indicate that acetylcholine, K or both may be the usual causative agent or agents.

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