An Evaluation of Erythropoiesis in Canine Marrow

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Abstract
Erythropoiesis in canine marrow was evaluated by an analysis of cell fluxes among the erythroid components after a single injection of tritiated thymidine in 3 dogs. Erythroid precursors had an average cell cycle time of about 10 hr. which could be subdivided into the following time components on average: pre-DNA [deoxyribonucleic acid] synthesis [image] 2 h: DNA synthesis[image]6 h; post-DNA synthesis [image] 1 h; mitosis [image]lh. The average age of a nondividing red cell at the beginning of nuclear pyknosis was [image] 12.5 h; there was a wide age distribution with a minimum age of 6 hr. No ineffective production was detected up to the orthochromatic stage before nuclear pyknosis. A crude comparison of the total dai?y production in marrow with the daily turnover in blood is suggestive of a 20% cell loss between the process of enucleation and entry into circulation.