Phylogenetic conservation of immimoglobulin heavy chains: direct comparison of hamster and mouse Cμ genes

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Abstract
We have analyzed the JH-Cμ locus of the Syrian hamster by DNA cloning and sequencing. The single Cμ gene is highly homologous to that of the mouse. The hamster equivalents of the JH and switch (S) recombination regions are arranged as in the mouse, but surprisingly are not highly conserved. Also unlike its close murine relative, the Sμ regions among inbred hamster strains are not polymorphic. The complete nucleotide sequence of hamster and mouse Cμ genes have been compared to partial Cμ sequences of other species. Conservation within a portion of the 3′ untranslated region may signify functional requirements for3′ end processing. Mutational frequencies within exons and introns of hamster and mouse do not support the theory that the rate of DNA transitions to transversions decreases with evolutionary distance.