COMPARISON OF ANTIBODY AVIDITY AND TITER ELICITED BY PEPTIDE AS A PROTEIN CONJUGATE OR AS EXPRESSED IN VACCINIA
- 1 October 1988
- journal article
- research article
- Vol. 65 (2) , 311-314
Abstract
The immunogenicity of a malaria peptide presented in various forms was tested in terms of the quality and quantity of the antibody response in rabbits. Peptide conjugated to a protein carrier, diphtheria toxoid (DT), required strong adjuvants (e.g. muramyl dipeptide, MDP and Freund''s adjuvant, FCA) to elicit high levels of antibody with high avidity. Alum was a poor adjuvant, producing the lowest titre and avidity of antibody compared with all the other groups. Peptide expressed in vaccinia (and without carrier) produced intermediate levels of antibody but the avidity of the antibodies produced were comparable to that produced by peptide conjugates given with muramyl dipeptide.This publication has 14 references indexed in Scilit:
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