The molecular choreography of a store-operated calcium channel
Top Cited Papers
- 1 March 2007
- journal article
- review article
- Published by Springer Nature in Nature
- Vol. 446 (7133) , 284-287
- https://doi.org/10.1038/nature05637
Abstract
Store-operated calcium channels (SOCs) serve essential functions from secretion and motility to gene expression and cell growth. A fundamental mystery is how the depletion of Ca2+ from the endoplasmic reticulum (ER) activates Ca2+ entry through SOCs in the plasma membrane. Recent studies using genetic approaches have identified genes encoding the ER Ca2+ sensor and a prototypic SOC, the Ca2+-release-activated Ca2+ (CRAC) channel. New findings reveal a unique mechanism for channel activation, in which the CRAC channel and its sensor migrate independently to closely apposed sites of interaction in the ER and the plasma membrane.Keywords
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