Response of Cloudman S91 Melanoma Cells to Melanocyte-Stimulating Hormone: Enhancement by Cytochalasin B2
- 1 May 1976
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 56 (5) , 1079-1081
- https://doi.org/10.1093/jnci/56.5.1079
Abstract
Cloudman S91 mouse melanoma cells treated for 5 days with melanocyte-stimulating hormone (MSH), cytochalasin B (CB), or both, exhibited changes in cell volume, population, nucleation, and pigment production. Cells treated with CB or CB in combination with MSH were eight to nine times larger, rounder, multinucleated, and heavily pigmented. CB alone increased melanin and DNA per nucleus threefold. CB in combination with MSH increased melanin per nucleus 30-fold. Data on DNA per nucleus suggest that CB-treated cells remained in the G2 phase longer than did control cells. MSH alone caused a reduction in cell population and a fourfold increase in melanin per nucleus.Keywords
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