Pharmacologic Preservation of Renal Mass and Function in Obstructive Uropathy

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Abstract
Unilateral ureteral obstruction for 1-, 2- and 3-wk intervals in rats resulted in a significant loss of renal mass and function as measured 3 mo. following relief of the obstruction. Inhibition of angiotensin II production by the administration of captopril during the period of obstruction resulted in significant preservation of both renal mass and function. Inhibition of the prostaglandin-thromboxane system with the cyclooxygenase inhibitor, indomethacin, resulted in a lesser degree of preservation of renal function but had no beneficial effect on renal mass. Apparently the renin-angiotensin and prostaglandin-thromboxane systems play a significant role in the loss of renal function from obstructive uropathy and renal function is better maintained if these hormonal systems are pharmacologically inhibited during obstruction.