Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF‐7 human breast cancer cell
Open Access
- 20 September 2002
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 102 (3) , 250-253
- https://doi.org/10.1002/ijc.10707
Abstract
Although the pharmacology and clinical application of water extracts of Ganoderma lucidum have been extensively documented, little is known regarding its alcohol extract. In the present study, the anti-tumor effect of an alcohol extract of Ganoderma lucidum was investigated using MCF-7 cells. We found that the alcohol extract of Ganoderma lucidum inhibited cell proliferation in a dose- and time-dependent manner, which might be mediated through up-regulation of p21/Waf1 and down-regulation of cyclin D1. Furthermore, this compound can directly induce apoptosis in MCF-7 cells, which might be mediated through up-regulation of a pro-apoptotic Bax protein and not by the immune system. Our findings suggest that there are multiple mechanisms underlying the anti-tumor effects of Ganoderma lucidum.Keywords
This publication has 19 references indexed in Scilit:
- The roles of ERK1/2 and p38 MAP kinases in the preventive mechanisms of mushroom Phellinus linteus against the inhibition of gap junctional intercellular communication by hydrogen peroxideCarcinogenesis: Integrative Cancer Research, 2002
- Preventive effects of vitamin C on carcinogenesisThe Lancet, 2002
- Protective effect of l-carnosine against 12-O-tetradecanoylphorbol-13-acetate- or hydrogen peroxide-induced apoptosis on v-myc transformed rat liver epithelial cellsCancer Letters, 2001
- Differential effect of vinorelbine versus paclitaxel on ERK2 kinase activity during apoptosis in MCF-7 cellsBritish Journal of Cancer, 2001
- ANTITUMORIGENIC AND CYTOTOXIC PROPERTIES OF AN ETHANOL EXTRACT DERIVED FROMRhus VernicifluaSTOKES (RVS)Journal of Toxicology and Environmental Health, Part A, 2001
- Preventive effect of germanium dioxide on the inhibition of gap junctional intercellular communication by TPACancer Letters, 2001
- Preventive effect of epicatechin and ginsenoside Rb2 on the inhibition of gap junctional intercellular communication by TPA and H2O2Cancer Letters, 2000
- In vitro chemopreventive effects of plant polysaccharides (Aloe barbadensis Miller, Lentinus edodes, Ganoderma lucidum and Coriolus versicolor)Carcinogenesis: Integrative Cancer Research, 1999
- The anti-tumor effect of Ganoderma Lucidum is mediated by cytokines released from activated macrophages and T lymphocytesInternational Journal of Cancer, 1997
- Ling Zhi-8: A Novel T Cell Mitogen Induces Cytokine Production and Upregulation of ICAM-1 ExpressionCellular Immunology, 1993