COLLAGEN CROSSLINKING IN KERATOCONUS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 171  (1) , 63-65
Abstract
The examination of reducible collagen crosslinks in keratoconus cornea [human] revealed the presence of lysinonorleucine in amounts far greater than in normal age-matched corneas. There was no indication of decreased hydroxylysine levels in keratoconus, and there were no clinical indications of a generalized connective tissue disorder. The abnormal levels of dehydrolysinonorleucine in the tissue may represent a change in hydroxylation of selected lysyl residues of normal collagen or the synthesis of abnormal collagen, perhaps an unusual type.

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