Relationship between acetylcholine tonus in isolated rabbit intestine

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Abstract
Acetylcholine content of bath fluid surrounding isolated rabbit intestinal strips was determined using the guinea pig ileum bioassay. In the 22 experiments performed, acetylcholine concentration of the rabbit bath was found to be directly proportional to the tonus manifested by the spontaneously contracting rabbit intestine at the time of assay. This relationship between tonus and acetylcholine content is statistically significant at the 99.5% confidence level. After the guinea pig ileum was atropinized it no longer responded to the rabbit bath fluid which had previously been shown to be stimulatory. It is concluded that the consistent and simple relationship between acetylcholine concentration and intestinal tonus indicates that acetylcholine is the principal factor in determining the tonus of isolated intestinal segments.

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