Isolation, Structure, and HIV-1 Integrase Inhibitory Activity of Cytosporic Acid, a Fungal Metabolite Produced by a Cytospora sp.
- 21 March 2003
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 66 (4) , 551-553
- https://doi.org/10.1021/np020533g
Abstract
HIV-1 integrase is a critical enzyme for replication of HIV, and its inhibition has the potential to lead to an anti-retroviral therapy that has advantages over existing therapies. Cytosporic acid (1) is a polyketide-derived novel natural product that was isolated from a fermentation broth of the filamentous fungus Cytospora sp. collected from Puerto Rico. It inhibited strand transfer reaction of HIV-1 integrase with an IC50 of 20 μM. The isolation, structure elucidation, relative stereochemistry, and activity of 1 are described.Keywords
This publication has 5 references indexed in Scilit:
- Inhibitors of Strand Transfer That Prevent Integration and Inhibit HIV-1 Replication in CellsScience, 2000
- Production of a Family of Kinase-inhibiting Lactones from Fungal.The Journal of Antibiotics, 1999
- Structure Elucidation of Australifungin, a Potent Inhibitor of Sphinganine N-Acyltransferase in Sphingolipid Biosynthesis from Sporormiella australisThe Journal of Organic Chemistry, 1995
- Structure and conformation of ophiobolin K and 6- epiophiobolin K from Aspergillus ustus as a nematocidal agent.Tetrahedron, 1991
- CoelomycetesPublished by CABI Publishing ,1980