Value of sperm morphology assessed by strict criteria for prediction of the outcome of artificial (intrauterine) insemination
- 1 June 1995
- journal article
- Published by Hindawi Limited in Andrologia
- Vol. 27 (3) , 143-148
- https://doi.org/10.1111/j.1439-0272.1995.tb01085.x
Abstract
Summary The purpose of this study was to investigate the relationship between sperm parameters and the outcome of artifical (intrauterine) insemination (IUI). One hundred and twenty‐six patients undergoing 395 consecutive IUI cycles in a 1‐year period in our institution were studied. In all cases, controlled ovarian stimulation and hCG‐timed IUI were performed, followed by progesterone supplementation of the luteal phase. In 86 patients, (243 cycles) the husband's sperm was utilized, whereas in 40 couples (152 cycles), donor sperm was used due to severe male factor infertility. Among the sperm parameters of the original ejaculate, % normal morphology (assessed by strict criteria) was the most significant predictor of pregnancy (stepwise regression analysis, P = 0.003). Using logistic regression, morphology was the best predictor of pregnancy (r = 0.12); linearity of movement significantly enhanced the predictive value of morphology alone (r = 0.17, P = 0.004). Overall, the pregnancy rates were significantly higher (P = 0.01) in cases with ≥ 14% normal morphology (15% per cycle) compared to cases with < 14% normal morphology (7% per cycle). This threshold level for morphology is in agreement with previously published IVF results. These results underscore the significance of sperm morphology assessed by strict criteria as a predictor of pregnancy outcome in the IUI setting.Keywords
This publication has 18 references indexed in Scilit:
- Predictive value of abnormal sperm morphology in in vitro fertilizationPublished by Elsevier ,2016
- Sperm morphology as diagnosed by strict criteria: probing the impact of teratozoospermia on fertilization rate and pregnancy outcome in a large in vitro fertilization populationFertility and Sterility, 1994
- Creatine kinase immunocytochemistry of human sperm-hemizona complexes: selective binding of sperm with mature creatine kinase-staining patternFertility and Sterility, 1994
- Prediction of fertilization in vitro with human gametes: Is there a litmus test?American Journal of Obstetrics and Gynecology, 1992
- Hemizona assay and its impact on the identification and treatment of human sperm dysfunctionsAndrologia, 1992
- Recurrent failure of in vitro fertilization: Role of the hemizona assay in the sequential diagnosis of specific sperm-oocyte defectsAmerican Journal of Obstetrics and Gynecology, 1991
- Controlled ovarian hyperstimulation and intrauterine insemination for treatment of infertilityFertility and Sterility, 1991
- Corrective measures and pregnancy outcome in in vitro fertilization in patients with severe sperm morphology abnormalitiesFertility and Sterility, 1988
- Superovulation with intrauterine insemination in the treatment of infertility: a possible alternative to gamete intrafallopian transfer and in vitro fertilizationFertility and Sterility, 1987
- Sperm morphologic features as a prognostic factor in in vitro fertilizationFertility and Sterility, 1986