Iturin AL - A new long chain iturin a possessing an unusual high content of C16-.BETA.-amino acids.

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Abstract
From a strain of Bacillus subtilis a new antifungal peptidolipid complex of the iturin group was isolated. This antibiotic complex contained 6 lipophilic .beta.-amino acids with 3-amino-14-methylpentanoic acid as the predominant component. Iturin AL contains: 2 D-Asp, 1 L-Asp, 1 L-Glu, 1 L-Pro, 1 L-Ser, 1 D-Tyr and a mixture of 2.9% iso-C14-.beta.-amino acid, 30.7% n-C14-.beta.-amino acid, 15% iso-C15-.beta.-amino acid, 9% anteiso-C15-.beta.-amino acid, 35.3% iso-C16-.beta.-amino acid and 4.5% n-C16-.beta.-amino acid. The structures of the .beta.-amino acids were determined by combined GLC/mass spectrometry. Fast atom bombardment mass spectroscopy revealed 3 M + H+ peaks (1043, 1057, 1071). Iturin AL was resolved into 6 components by high performance liquid chromatography whose structures confirm the high amount of long chain .beta.-amino acids.