Cx-Reactive Protein Responses in the Rabbit after Whole-Body Irradiation

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Abstract
Cx-protein was present in the serum of all rabbits exposed to whole-body doses of 250 to 750 r of X-rays 24 hours after exposure, and the maximum Cx-protein titer was usually observed at this time. Not all animals gave a Cx-protein titer 24 hours after 100 r or less. The mean 24-hour titer was about the same after doses of 100 to 750 r. The response was commonly biphasic in fed rabbits and monophasic in rabbits denied food during the postirradiation period. Treatment with compound 48/80 produced a Cx-protein response and animals so treated behaved like controls when subsequently given 250 r. Pyrilamine did not modify the Cx-protein response to 250 r of X-rays.