Clean solvent-free dipolar cycloaddition reactions assisted by focused microwave irradiations for the synthesis of new ethyl 4-cyano-2-oxazoline-4-carboxylates
- 21 July 2000
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Green Chemistry
- Vol. 2 (5) , 226-229
- https://doi.org/10.1039/b003384g
Abstract
1,3-Dipolar cycloaddition reactions without solvent under focused microwave irradiation are reported. Imidate 3, derived from ethyl α-cyano α-amino acetate as potential azomethine ylide, undergoes highly regioselective cycloadditions to a wide range of aldehydes 4a–f as dipolarophiles in short reaction times. This simple, efficient and environmentally-friendly methodology has been applied to the synthesis of new ethyl 4-cyano-2-oxazoline-4-carboxylates 6a–f in good yields (81–98%) and moderate diastereoisomeric ratios.Keywords
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