FAMILIAL HISTORY OF CORONARY HEART-DISEASES AND HIGH BLOOD-PRESSURE IN RELATION TO THE PREVALENCE OF RISK-FACTORS, AND THE INCIDENCE OF CORONARY HEART-DISEASES - THE PARIS PROSPECTIVE-STUDY

  • 1 January 1980
    • journal article
    • research article
    • Vol. 28  (1) , 21-37
Abstract
In the Paris [France] Prospective Study, 7484 men from the same professional group, 43-54 yr old, were followed for 6.5 yr. The incidence of coronary heart disease (CHD) was studied among those free of CHD at entry in relation to parental history of CHD and high blood pressure (HBP). In the presence of paternal history of CHD, the relative risk is 1.5, in the presence of paternal history of HBP, the relative risk is 2 (after exclusion of subjects with HBP). The risk factors age, blood pressure, cholesterol, diabetes and cigarette smoking explain only a small part of the higher risk. Maternal history of CHD or HBP is not associated with a higher risk. The classical risk factors, paternal history of CHD and paternal history of HPB all contribute independently to the risk of CHD. The simultaneous presence of the last 2 is associated with a relative risk of 3.