The Regional Concentrations of S‐Adenosyl‐l‐Methionine, S‐Adenosyl‐l‐Homocysteine, and Adenosine in Rat Brain

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Abstract
The concentrations of S‐adenosyl‐l‐methionine (SAM), S‐adenosyl‐l‐homocysteine (SAH), and adenosine (Ado) were determined in whole brain and rat brain regions by HPLC. The whole brain contains, respectively, 22 nmol, 1 nmol, and 64 nmol of SAM, SAH, and Ado per g of wet tissue. Their distribution indicated that SAM and SAH levels are highest in brainstem, whereas the Ado level is highest in cortex. With aging the SAM concentrations decrease in whole brain, brainstem, and hypothalamus (–25%) and SAH levels increase by 90% in striatum and by 160% in cerebellum, while Ado levels are increased in all regions by 100–180%.