Electrophysiological and behavioral reactivity to photic stimuli following septal lesions and pharmacological treatments in rats.
- 1 January 1975
- journal article
- Published by American Psychological Association (APA) in Journal of Comparative and Physiological Psychology
- Vol. 88 (1) , 128-146
- https://doi.org/10.1037/h0076271
Abstract
Analysis of behavioral reactivity and cortical visual evoked response (VER) to photic stimulation revealed 2 patterns of lesion-induced changes. One pattern of VERs reflected a hypoarousal electrophysiological condition. This pattern, present initially under all conditions, could be simulated with administration of scopolamine. A second pattern of VERs developed gradually and appeared to reflect a hyperaroused electrophysiological condition. This pattern could be simulated with d-amphetamine. While both lesion-induced electrophysiological patterns were associated with augmented behavioral reactivity to flashes, the hyperarousal pattern related to more intense conditions of stimulation and more sustained behavioral reactivity. Scopolamine, as opposed to d-amphetamine, reproduced the heightened behavioral reactivity to the flashes. These results were interpreted in terms of a "hypoarousal hypothesis" of sensory hyperreactivity.Keywords
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