Preparation of Optically Purecis-2,4-Dimethyl-l-cyclohexanones, the Key Intermediates in Cycloheximide Synthesis, Using Microbial Resolution
- 1 March 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Agricultural and Biological Chemistry
- Vol. 46 (3) , 757-760
- https://doi.org/10.1080/00021369.1982.10865119
Abstract
Asymmetric hydrolysis of acetate (10) of (±)-t-2,t-4-dimethyl-r-l-cyclohexanol with Bacillus subtilis var. niger gave (−)-(lS,2S,4S)-2,4-dimethyl-l-cyclohexanol (6a) and (+)-(1R,2R,4R)-acetate (10b) with high optical purities. Optically pure (−) and (+)-alcohols (6a and 6b) were prepared via corresponding 3,5-dinitrobenzoates. Oxidation of alcohols (6a and 6b) with chromic acid gave optically pure (−)-(2S,4S) and (+)-(2R,4R)-2,4-dimethyl-l-cyclohexanones (2a and 2b), respectively.This publication has 3 references indexed in Scilit:
- Enzymic Resolution of (± )-Unsaturated Cyclic Terpene AlcoholsviaAsymmetric Hydrolysis of Corresponding Acetates by MicroorganismsAgricultural and Biological Chemistry, 1980
- Enzymic Resolution of (±)-Acyclic AlcoholsviaAsymmetric Hydrolysis of Corresponding Acetates by MicroorganismsAgricultural and Biological Chemistry, 1980
- The Production, Assay, and Antibiotic Activity of Actidione, an Antiobiotic from Streptomyces griseusJournal of Bacteriology, 1948