One Disease, Two Epidemics — AIDS at 25

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Abstract
Twenty-five years have passed since the first cases of AIDS were recognized. During the first two decades, the epidemiology and clinical presentation of the disease were established, and potent antiviral therapies were developed — for use in patients who could afford them. The progress of the past five years has been less dramatic. Indeed, the most salient change was a widening of the gap between the haves and the have-nots, so that today a single virus is responsible for two distinct public health calamities.