Particles in small volume injections
- 1 December 1983
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 35 (12) , 769-773
- https://doi.org/10.1111/j.2042-7158.1983.tb02894.x
Abstract
The level of particulate contamination in small volume injections has been examined using the light blockage (HIAC) and electrical sensing zone (Coulter counter) techniques, the HIAC system being found to be the more suitable. Particle counts on the same batch of injection showed a large and variable difference between the HIAC and the Coulter counter results, especially below 5 μm. None of the injections examined complied with the British Pharmacopoeia limits for particulates in large volume parenterals, suggesting the unsuitability of the limits for small volume parenterals.This publication has 4 references indexed in Scilit:
- Particle Size Analysis and quality control for pharmaceuticalsAnalytical Proceedings including Analytical Communications, 1981
- Particulate contamination in selected parenteral drugsCanadian Journal of Anesthesia/Journal canadien d'anesthésie, 1980
- Evaluation of Acceptance Criteria for Particulate Limits for Small-Volume Parenteral ProductsJournal of Pharmaceutical Sciences, 1978
- A comparison of instrumental techniques for the determination of contamination in filtered aqueous solutionsPowder Technology, 1977