Expression of Restricted Immunoglobulin Isotypes in Plasmacellular Hyperplasia after Allogeneic Bone Marrow Transplantation

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Abstract
Plasmacellular hyperplasia in lymphoid tissue was found in 4 out of 9 patients 1‐6 months after allogeneic bone marrow transplantation as treatment for leukaemia. In the plasma cell populations. 13‐85% expressed a single immunoglobulin light and heavy chain isotype (monotypic Ig expression). DNA analysis, using a DNA probe specific for heavy chain JH gene segments and for light chains, did not reveal the presence of clonally restricted B lymphocytes. The patients' sera lacked homogeneous immunoglobulins. We conclude that plasmacellular hyperplasia found after allogeneic bone marrow transplantation represents a polyclonal B‐cell expansion‐with a restriction in Ig isotype.