Location of epicardial pacemaker electrodes and myocardial contractility

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Abstract
Effects of pacing from different epicardial sites on cardiac contractility were studied in the isolated perfused rat heart. An indwelling balloon containing a known volume of saline was used to record intracavitary pressure (LVP), force, and maximum dp/dt during isovolumic paced contraction. Coronary flow was kept constant, and the adequacy of oxygenation was verified by lactate extraction. Forty male Sprague–Dawley rats weighing 250–300 g were divided into two groups, according to the rate of pacing, and stimulated. Pacing from four different epicardial sites failed to show any statistically significant difference in LVP, force, or maximum dp/dt at either different heart rate or calcium concentration. The present study suggests that myocardial contractility in the isolated perfused rat heart is not affected by the pacing site of the epicardial pacemaker.

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