VARIATION OF CORTISOL METABOLISM AS A CONTRIBUTING FACTOR TO DISCREPANCIES IN THE MEASUREMENT OF CORTISOL PRODUCTION RATE

1 May 1972

journal article
Published by Oxford University Press (OUP) in Acta Endocrinologica

Vol. 70 (1) , 89-96
https://doi.org/10.1530/acta.0.0700089

Abstract

Five normal subjects were given [¹⁴C] cortisol in the morning and [³H] cortisol in the evening, in both cases by mouth. The excretion of radioactivity in tetrahydrocortisol (THF) and tetrahydrocortisone (THE) was measured by a modified form of reverse isotope dilution. In 2 subjects, the ratio of isotopic THF/isotopic THE was higher after the evening dose than after the morning dose. In 1 subject the ratio decreased. In 2 subjects it did not change. Cortisol production rates calculated from THF were usually higher than those calculated from THE. The observed variations of metabolism were only a contributory factor to these discrepancies.

Keywords

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