Protein model quality assessment prediction by combining fragment comparisons and a consensus Cα contact potential
- 14 November 2007
- journal article
- research article
- Published by Wiley in Proteins-Structure Function and Bioinformatics
- Vol. 71 (3) , 1211-1218
- https://doi.org/10.1002/prot.21813
Abstract
In this work, we develop a fully automated method for the quality assessment prediction of protein structural models generated by structure prediction approaches such as fold recognition servers, or ab initio methods. The approach is based on fragment comparisons and a consensus Cα contact potential derived from the set of models to be assessed and was tested on CASP7 server models. The average Pearson linear correlation coefficient between predicted quality and model GDT‐score per target is 0.83 for the 98 targets, which is better than those of other quality assessment methods that participated in CASP7. Our method also outperforms the other methods by about 3% as assessed by the total GDT‐score of the selected top models. Proteins 2008.Keywords
Funding Information
- Division of General Medical Sciences of the National Institutes of Health (GM-37408, GM-48835)
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