FURTHER STUDIES ON CARBOHYDRATE METABOLISM IN THE VITAMIN-B6-DEPRIVED RAT

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Abstract
Following 3 weeks of vitamin B6 restriction, rats have significantly elevated levels of inorganic P and glutathione in blood and liver. These elevations in blood inorganic P and glutathione levels were similarly demonstrated after only 1 week of vitamin Bg deprivation. Contrary to changes in liver glycogen levels, muscle glycogen levels are not altered by vitamin Bg deprivation in the rat. Insulin administration had a slightly more pronounced effect on blood sugar levels in vitamin-B6-deprived than in pair-fed control rats. Alloxan administration elevated blood sugar levels of deprived rats to a slightly greater extent than the levels of controls. In accord with earlier studies, disturbances of carbohydrate metabolism can be readily demonstrated in vitamin-Bg-deprived rats.