A monoclonal antibody (1B7) specific for polymorphic determinant on mouse I‐A antigens recognizes monomorphic epitope shared by most of RT‐1 haplotypes in rats

1 October 1986

journal article
research article
Published by Wiley in Tissue Antigens

Vol. 28 (4) , 233-236
https://doi.org/10.1111/j.1399-0039.1986.tb00488.x

Abstract

A monoclonal antibody, 1B7, which was established by immunizing C57BL/10 mice with splenocytes from B10.BR, was investigated by serological, immunochemical and functional analyses in mouse, rat, guinea pig and human systems. 1B7 recognized a polymorphic determinant on class II antigens in the mouse system. In the rat system, however, this antibody appeared to recognize a monomorphic epitope shared by all RT‐1 haplotypes. 1B7 showed no reactivity in the human and guinea pig strains tested.

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