SUPRARENAL CORTICAL EXTRACTS IN SUPRARENAL INSUFFICIENCY (ADDISON'S DISEASE)

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Abstract
It is generally assumed that Addison's disease and some other clinical conditions associated with low blood pressure are due to interference with epinephrine secretion from the suprarenal glands. This assumption is based on the fact that the medulla of these glands contains and secretes a blood pressure raising principle (epinephrine). However, the idea that these conditions result from a lack of this secretion is not supported by experimental evidence or by the results obtained in treating such cases by the administration of epinephrine. Our studies have led to the conclusion that we must consider Addison's disease (and other, less severe, forms of suprarenal insufficiency) as resulting from interference with the function of thecortexrather than the medulla of the suprarenal glands. It has been established, experimentally, that epinephrine secretion from the suprarenals is not indispensable for life and good health, since it can be suppressed, in animals, without harmful

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