Development of in Vivo Cecal and Colonic Calcium Fluxes in Growing Rats

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Abstract
Small intestinal Ca transport correlates with body growth rates and and declines with increasing age, but effects of age on Ca transport by large intestine were not examined. Groups of rats were studied at mean ages of 4, 7, and 10 wk. Cecal and colonic net Ca absorption and unidrectional fluxes were measured by in situ luminal perfusion of 1.6 mM Ca. Rates/g dry tissue declined with age in both segments, except for colonic plasma-to-lumen flux. Rates per segment reflected progressive tissue growth. Lumen-to-plasma fluxes and cecal net absorption increased slightly, colonic net absorption was maintained and colonic plasma-to-lumen flux doubled. In contrast to small intestine, total contribution of cecum to Ca homeostasis increases slightly with age. The colon may be responsible for the increasing loss of fecal endogenous Ca with decreasing body growth reported by isotopic studies.

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