Substitutions of Asn-726 in the Active Site of Yeast DNA Topoisomerase I Define Novel Mechanisms of Stabilizing the Covalent Enzyme-DNA Intermediate
Open Access
- 1 May 2000
- journal article
- Published by Elsevier
- Vol. 275 (20) , 15246-15253
- https://doi.org/10.1074/jbc.275.20.15246
Abstract
No abstract availableKeywords
This publication has 32 references indexed in Scilit:
- Structural insights into the function of type IB topoisomerasesCurrent Opinion in Structural Biology, 1999
- Structure of DNA topoisomerasesBiochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998
- Mechanism of action of eukaryotic DNA topoisomerase I and drugs targeted to the enzymeBiochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998
- Clinical applications of the camptothecinsBiochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998
- Yeast as a model organism for studying the actions of DNA topoisomerase-targeted drugsBiochimica et Biophysica Acta (BBA) - Gene Structure and Expression, 1998
- Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNAScience, 1998
- Conservation of Structure and Mechanism between Eukaryotic Topoisomerase I and Site-Specific RecombinasesCell, 1998
- Analysis of comptothecin resistance in yeast: relevance to cancer therapyDrug Resistance Updates, 1998
- DNA TOPOISOMERASESAnnual Review of Biochemistry, 1996
- DNA Topoisomerases: Essential Enzymes and Lethal TargetsAnnual Review of Pharmacology and Toxicology, 1994