Porphyrinogens in Plasma

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Abstract
To the Editor.— For some time, we have been studying porphyrins and, especially, their colorless precursors, porphyrinogens, in plasma. For their determination, we use direct spectrofluorometry. We call attention to the excellent results of Poh-Fitzpatrick, who described the differentiation of various types of porphyrias by the use of direct spectrofluorometry of diluted plasma in the May 1980 619 680 619 680 626 687 626 687 Fluorescence Emission Maximum, nm Fig 1.—Fluorescence emission spectrum of plasma from patient with acute intermittent porphyria at left. Fluorescence emission spectrum 1 indicates amount of porphyrins present in oxidized form (without Lugol's solution as oxidation agent); 2 indicates total amount of porphyrins after oxidation of porphyrinogens to corresponding porphyrins. Fluorescence emission spectrum of plasma from patient with variegate porphyria at right. Fluorescence emission spectrum 1 indicates amount of porphyrins present in oxidized form (without Lugol's solution as oxidation agent); 2 indicates total amount of porphyrins

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