Studies on the polyoma tumor-specific transplantation antigen (TSTA): Selection and characterization of TSTA-negative segregants from somatic hybrids
- 15 July 1987
- journal article
- research article
- Published by Wiley in International Journal of Cancer
- Vol. 40 (1) , 74-80
- https://doi.org/10.1002/ijc.2910400114
Abstract
Two polyoma‐TSTA‐negative variants were selected independently from a polyoma fibrosarcoma/Moloney lymphoma somatic hybrid, by repeated passages in polyoma‐virus‐preimmunized mice. One of the variants had lost all its polyoma DNA, while the other only retained a deleted piece of its integrated polyoma DNA. In contrast to the parental hybrid clone, none of the variants produced detectable amounts of T‐antigens. This finding indicates that a detectable expression of the products of the polyoma virus early genome, the T‐antigens, is important either directly or indirectly for the expression of TSTA.This publication has 29 references indexed in Scilit:
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