Prostaglandin and thromboxane biosynthesis inhibitors
- 1 January 1977
- journal article
- research article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 297 (S1) , S85-S88
- https://doi.org/10.1007/bf00587789
Abstract
Summary All acidic non-steroidal anti-inflammatory drugs suppress the activity of microsomal cyclo-oxygenase of arachidonic acid; therefore, these drugs are equipotent inhibitors of prostaglandin and thromboxane generation. A non-acidic anti-inflammatory agent, 1′- (isopropyl-2-indolyl)-3-pyridyl-3-ketone (L 8027), selectively inhibits biosynthesis of thromboxane A2 in blood platelets and in lungs.Keywords
This publication has 11 references indexed in Scilit:
- Thromboxanes: Selective Biosynthesis and Distinct Biological PropertiesScience, 1976
- The effects of prostagladin endoperoxides and thromboxane A2 on strips of rabbit coeliac artery and certain other smooth muscle preparations [proceedings].1976
- Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxidesNature, 1976
- Inhibition of human platelet aggregation by oral administration of nicergoline. A double-blind study.1975
- The influence of saturated fatty acids on prostaglandin synthetase activityBiochemical Pharmacology, 1975
- Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides.Proceedings of the National Academy of Sciences, 1975
- [In vitro inhibition of the biosynthesis of E 2 prostaglandin by anti-inflammatory drugs].1971
- Prostaglandins released by the SpleenNature, 1968
- THE USE OF ISOLATED ORGANS FOR DETECTING ACTIVE SUBSTANCES IN THE CIRCULATING BLOODBritish Journal of Pharmacology and Chemotherapy, 1964