Heme Oxygenase and the Kidney
- 1 April 2002
- journal article
- review article
- Published by Mary Ann Liebert Inc in DNA and Cell Biology
- Vol. 21 (4) , 307-321
- https://doi.org/10.1089/104454902753759726
Abstract
Heme plays a significant pathogenic role in several diseases involving the kidney. The cellular content of heme, derived either from the delivery of filtered heme proteins such as hemoglobin and myoglobin, or from the breakdown of ubiquitous intracellular heme proteins, is regulated via the heme oxygenase enzyme system. Heme oxygenases catalyze the rate-limiting step in heme degradation, resulting in the formation of iron, carbon monoxide, and biliverdin, which is subsequently converted to bilirubin by biliverdin reductase. Recent attention has focused on the biological effects of product(s) of this enzymatic reaction, which have important antioxidant, anti-inflammatory, and cytoprotective functions. Three isoforms of heme oxygenase (HO) enzyme have been described: an inducible isoform, HO-1, and two constitutively expressed isoforms, HO-2 and HO-3. Induction of HO-1 occurs as an adaptive and beneficial response to several injurious stimuli, and has been implicated in many clinically relevant disease states including atherosclerosis, transplant rejection, endotoxic shock, hypertension, acute lung injury, acute renal injury, as well as others. This review will focus predominantly on the role of HO-1 in the kidney.Keywords
This publication has 148 references indexed in Scilit:
- Cobalt Induces Heme Oxygenase-1 Expression by a Hypoxia-inducible Factor-independent Mechanism in Chinese Hamster Ovary CellsJournal of Biological Chemistry, 2001
- The case of CO signaling: why the jury is still outJournal of Clinical Investigation, 2001
- Induction of Heme Oxygenase-1 Can Act Protectively against Cardiac Ischemia/Reperfusion in VivoBiochemical and Biophysical Research Communications, 2000
- Heme Oxygenase-1 in Tissue PathologyThe American Journal of Pathology, 2000
- Peroxynitrite induces haem oxygenase-1 in vascular endothelial cells: a link to apoptosisBiochemical Journal, 1999
- Carbon Monoxide Enhances Human Neutrophil Migration in a Cyclic GMP-dependent WayBiochemical and Biophysical Research Communications, 1996
- The Heme-Responsive Element of the Mouse Heme Oxygenase-1 Gene Is an Extended AP-1 Binding Site That Resembles the Recognition Sequences for MAF and NF-E2 Transcription FactorsBiochemical and Biophysical Research Communications, 1996
- Induction of the antioxidant stress proteins heme oxygenase‐1 and MSP23 by stress agents and oxidised LDL in cultured vascular smooth muscle cellsFEBS Letters, 1995
- Heme and the Vasculature: an Oxidative Hazard that Induces Antioxidant Defenses in the EndotheliumArtificial Cells, Blood Substitutes, and Immobilization Biotechnology, 1994
- Antiarrhythmic Drugs: Electrophysiological and Pharmacokinetic ConsiderationsAnnual Review of Pharmacology, 1975