Prophylactic Effect of L-5-Hydroxytryptophan on Self-Mutilation in the Lesch-Nyhan Syndrome
- 1 February 1975
- journal article
- research article
- Published by Georg Thieme Verlag KG in Neuropediatrics
- Vol. 6 (01) , 13-23
- https://doi.org/10.1055/s-0028-1091647
Abstract
Four cases of the Lesch-Nyhan syndrome found in the Tokyo area were given L-5-hydroxytryptophan orally. L-5-hydroxytryptophan relieved self-mutilation effectively without causing any side effects. However this substance did not alleviate choreoathetoid movement. Self-destructive behavior may be caused by an imbalance of cerebral amines, especially of serotonin.Keywords
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