Total and Individual Kidney Function Assessment with Iodine-123 Ortho-iodohippurate

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Abstract
A simple and reliable method of preparing 123I o-iodohippurate (I-123 OIH) was described. The agent was used to evaluate renal function in 329 patients; its use results in significant dose reduction for those with obstruction, hypertension or transplant. Images from I-123 OIH provided 2.4 times more detectable photons/mCi administered to the patient than images obtained from I-131 OIH. Diagnoses are expected to be more reliable with I-123 OIH due to the decreased random variation of each data point.